Protein phosphorylation during Plasmodium berghei gametogenesis

A mitogen-activated protein kinase regulates male gametogenesis and transmission of the malaria parasite Plasmodium berghei.

Differentiation of malaria parasites into sexual forms (gametocytes) in the vertebrate host and their subsequent development into gametes in the mosquito vector are crucial steps in the completion of the parasite's life cycle and transmission of the disease. The molecular mechanisms that regulate the sexual cycle are poorly understood. Although several signal transduction pathways have been imp...

Gametogenesis in Plasmodium.

Expression and processing of Plasmodium berghei SERA3 during liver stages

Cysteine proteases mediate liberation of Plasmodium berghei merozoites from infected hepatocytes. In an attempt to identify the responsible parasite proteases, we screened the genome of P. berghei for cysteine protease-encoding genes. RT-PCR analyses revealed that transcription of four out of five P. berghei serine repeat antigen (PbSERA) genes was strongly upregulated in late liver stages brie...

Palm Oil Supplementation Prevents Further Tyrosine Dephosphorylation of Erythrocytes 30-kda Protein during Plasmodium Berghei Infection

This study was carried out to determine effect of palm oil (PO) supplementation on erythrocytes phosphotyrosine proteins in Plasmodium berghei (PB) infection. A number of 40 experimental mice were divided into observation (n=20) and sampling (n=20) groups which were then subdivided into four groups (group A: +PO+PB; group B: +POPB; group C: -PO+PB and group D: -PO-PB) with n=5 each. It was obse...

Plasmodium berghei EXP-1 interacts with host Apolipoprotein H during Plasmodium liver-stage development.

The first, obligatory replication phase of malaria parasite infections is characterized by rapid expansion and differentiation of single parasites in liver cells, resulting in the formation and release of thousands of invasive merozoites into the bloodstream. Hepatic Plasmodium development occurs inside a specialized membranous compartment termed the parasitophorous vacuole (PV). Here, we show ...